Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development
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چکیده
منابع مشابه
Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.
Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function. BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development, brain development, metabolic disease and post-natal behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane) and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylide...
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Although UDP-glucuronosyltransferases (UGTs) are important phase II drug-metabolizing enzymes, they are also involved in the metabolism of endogenous compounds. Certain substrates of UGTs, such as serotonin and estradiol, play important roles in the brain. However, the expression of UGTs in the human brain has not been fully clarified. Recently, humanized UGT1 mice (hUGT1 mice) in which the ori...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2015
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.15-0197